CURRICULUM VITAE

MALACHI EDWARD QUIGLEY, M.D.

Specialty: Infertility, Reproductive Endocrinology, OB/GYN

PERSONAL INFORMATION:

Birthplace:             London, Ontario, Canada

College:                   University of Western Ontario                    

                                    B.A. - Chemistry  (1968)

Medical School:     University of Western Ontario                    

                                     M.D.  (1972)

Internship:               Victoria Hospital, London, Ontario (1972-1973)

Residency:               Victoria, St. Joseph’s and University Hospitals, affiliated with University of Western Ontario, London, Ontario, Canada(1973-1976)                                                                                            

Fellowship:           Fellow in Reproductive Endocrinology in the Department of Reproductive Medicine,   University of California, San Diego(1977-1979)

 

PROFESSIONAL EXPERIENCE: 

Post-Graduate Fellow, University Hospital, London, Ontario, Canada (1976)                                                                                                                                       

Assistant Professor, Department of Reproductive Medicine School of Medicine,  University of California, San Diego  (1979-1982)                                                                                                                                              

Clinical Associate Physician, GCRC, UCSD  (1981-1982)                                                                                                                                                            

Clinical Associate Professor, UCSD Department of Reproductive Medicine  (1982-2014)                                                                                                                             

Clinical Associate Professor, UCSD Department of Family Medicine  (1990-2014)

Fertility and Gynecology Foundation, private practice  (1982-1993)

Infertility, Gynecology and Obstetrics Medical Group, private practice  (1993-2014)

 

PAST AND PRSENT SOCIETY MEMBERSHIPS:

Fellow, American College of Obstetricians and Gynecologists

Society of Obstetricians and Gynecologists of Canada

California Medical Association

The Endocrine Society

North American Menopause Association

American Medical Association

National Academy of Science

International Society for Psychoneuroendocrinology

Society for Gynecologic Investigation

Pacific Coast Fertility Society

San Diego County Medical Society

San Diego Gynecological Society

Pacific Coast Obstetrics and Gynecology Society

 

LICENSED TO PRACTICE: 

Ontario, Canada

California

 

CERTIFIED BY:

American Board of Obstetrics and Gynecology  (1981)

American Board of Obstetrics and Gynecology, Division of Reproductive Endocrinology  (1981)                                                                                        

F.R.C.S. ©  (1976)                                           

F.L.E.X.  (1977)                                                                                                      

 

OTHER PROFESSIONAL ACTIVITIES:

Clinical Research Center Advisory UCSD  (1979-1982)

Medical Audit Committee, University Hospital, UCSD  (1979-1982)

Course Curriculum Committee, UCSD  (1980-1982)

Reproductive Medicine Resident Selection Committee, UCSD  (1979-1982)

Medical School Admission Committee, UCSD  (1981-1982)

Director, Infertility and Endocrinology Clinics, Mercy Hospital and Medical Center, San Diego, California              (1982-1986)

Obstetrics and Gynecology Advisory Committee Mercy, Hospital and Medical Center, San Diego, California               (1986-1991)

Clinical Research Committee Sharp Memorial Hospital, San Diego, California (1986-1988)

In Vitro Fertilization -- Sharp Hospital, San Diego, California  (1984-1988)

Scripps Memorial Hospital, La Jolla, California  (1993-2014)

 

HOSPITAL PRIVILEGES: 

Scripps Memorial Hospital  (1993-2014)

UCSD - Thornton Hospital  (1994-2014)

 

BIBLIOGRAPHY:

1. Quigley, M.E., Sheehan, K.L., Wilkes, M.M., and Yen, S.S.C. “Effects of Maternal Smoking on Circulating Catecholamine Levels and Fetal Heart Rates.” Am J Obstet Gynecol, 133:685-689, 1979.

2. Quigley, M.E., Judd, S.J., Gilliland, G.B., and Yen, S.S.C. “Effects of a Dopamine Antagonist on the Release of Gonadotropin and Prolactin in Normal Women and Women with Hyperprolactinemic Anovulation.” J Clin Endocrinol Metab, 48: 718-720, 1979. 

3. Wilkes, M.M., Stewart, R.D., Bruni, J.F., Quigley, M.E.,  and Yen, S.S.C. “A Specific Homologous Radioimmunoassay for Human B-Endorphin: Direct Measurement in Biological Fluids.” J Clin Endocrinol Metab 50:309-315, 1980. 

4. Quigley, M.E., and Yen, S.S.C. “Evidence for Increased Dopaminergic Inhibition of Secretion of Thyroid-Stimulating Hormone in Hyperprolactinemic Patients with Pituitary Microadenoma.” Am J Obstet Gynecol 137:653-655, 1980.

5. Quigley, M.E., and Yen, S.S.C. “A Mid-Day Surge in Cortisol Levels.” J Clin Endocrinol Metab 49:945-947, 1979. 

6. Erickson, G.F., Hsueh, A.J.W., Quigley, M.E., Rebar, R.W., and Yen, S.S.C. “Functional Studies of Aromatase Activity in Human Granulosa Cells from Normal and Polycystic Ovaries.” J Clin Endocrinol Metab 49: 514-519, 1979. 

7. Quigley, M.E., Sheehan, K.L., Casper, R.F.,  and Yen, S.S.C. “Evidence for an Increased Dopamineric and Opiod Inhibition of Luteinizing Hormone Secretion in Hyperprolactinemic Patients with Pituitary Microadenoma.” J Clin Endocrinol Metab 50: 427-430, 1980. 

8. Quigley, M.E., Sheehan, K.L., Casper, R.F., and Yen, S.S.C. “Evidence for an Increased Dopamineric and Opioid Activity in Patients with Hypothalamic Hypogonadotropic Amenorrhea.” J Clin Endocrinol Metab 50: 949-954, 1980.

9. Quigley, M.E., Judd, S.J., Gilliland, G.D., and Yen, S.S.C. “Functional Studies of Dopamine Control of Prolactin Secretion in Normal Women and Women with Hyperprolactinemic Pituitary Microadenoma.” J Clin Endocrinol Metab 50: 994-998, 1980.

10. Casper, R.F., Rakoff, J.S., Quigley, M.E., Gilliland, G.B., Alksne, J., and Yen, S.S.C. “Changes in Pituitary Hormones During and Following Transsphenoidal Removal of Prolactinomas.” Amer J Obstet Gynecol 136: 518, 1980.

11. Quigley, M.E., Rakoff, J.S., and Yen, S.S.C. “Increased Luteinizing Hormone Sensitivity to Dopamine Inhibition in Polycystic Ovary Syndrome.” J Clin Endocrinol Metab 52: 231-234, 1981. 

12. Quigley, M.E., and Yen, S.S.C. “The Role of Endogenous Opiates on LH Secretion During the Menstrual Cycle.” J Clin Endocrinol Metab 51: 179-181, 1980.

13. Ropert, J.F., Quigley, M.E., and Yen, S.S.C. “Endogenous Opiates Modulate Pulsatile Luteinizing Hormone Release in Humans.” J Clin Endocrinol Metab 52: 583-585, 1981. 

14. Wilkes, M.M., Babaknia, A., Hoff, J.D., Quigley, M.E., Kraus, P.F., and Yen, S.S.C. “Circadian Rhythm in Circulating Concentration of Dihydroxyphenylacetic Acid in Normal Women.” J Clin Endocrinol Metab  52: 608-611, 1981. 

15. Quigley, M.E., Ropert, J.F., and Yen, S.S.C. “Acute Prolactin Release Triggered by Feeding.” J Clin Endocrinol Metab  52: 1043-1045, 1981. 

16. Ropert, J.F., Quigley, M.E., and Yen, S.S.C. “The Dopaminergic Inhibition of LH Secretion During Menstrual Cycle.” Life Science 34: 2067-2073, 1984. 

17. Hennessy, D.P., Hardy, K.J., Quigley, M.E., Wintour, E.M., and Yen, S.S.C. “Immunoreactive B-Endorphin/Lipotrophin in the Chronically Cannulated Ovine Fetus: Response to bilateral fetal adrenalectomy.” Acta Endocrinologica 99: 000-000, 1982. 

18. Quigley, M.E., Ishizuka, B., Ropert, J.F., and Yen, S.S.C “The Food-Entrained Prolactin and Cortisol Release in Late Pregnancy and Prolactinoma Patients.” J Clin Endocrine Metab. 

19. Quigley, M.E. “Hypothalamic Inhibitory Influences of Gonadotropin Secretion in Normal Cycling and Hypogonadotropic Amenorrheic Women.” in Neuroendocrinology and Psychiatric Disorders, ed. by G.M. Brown, S.H. Koslov and S. Reichlin, Raven Press, pp. 357-370, 1984. 

20. Ishizuka, B., Yen, S.S.C., and Quigley, M.E. “Postpartum Hypogonadotropinism: Evidence for Increased Opioid Inhibition.” Clin Endocrinology 20: 573-578, 1984.

21. Cummning, D.C., Quigley, M.E., and Yen, S.S.C. “Acute Suppression of Circulating Testosterone Levels by Cortisol in Men.” J Clin Endocrinol Metab 57:671-673, 1983. 

22. Ishizuka, B., Quigley, M.E., and Yen, S.S.C. “Pituitary Hormone Release in Response to Food Ingestion; Evidence for Neuroendocrine Signals from Gut to Brain.” J Clin Endocrinol Metab 57: 1111-1116, 1983. 

23. Rasmussen, D.D., Ishizuka, B., Quigley, M.E., and Yen, S.S.C. “Effects of Tyrosine and Tryptophan Ingestion on Plasma Catecholamine and 3,4 Dihydroxyphenylacetic Acid Concentration.” J Clin Endocrinol Metab 57: 760-763, 1983. 

24. Reid, R.L., Quigley, M.E., and Yen, S.S.C. “The Disappearance of Opioidergic Regulation of Gonadotropin Secretion in Postmenopausal Women.” J Clin Endocrinol Metab 57: 1107-1110, 1983. 

25. Cumming, D.C., Reid, R.L., Quigley, M.E., Rebar, R.W., and Yen, S.S.C. “Evidence for Decreased Endogenous Dopamine and Opioid Inhibitory Influences on LH Secretion in Polycystic Ovarian Syndrome.” Clin Endocrinol 20: 643-648, 1984. 

26. Hoff, J.H., Quigley, M.E., and Yen, S.S.C. “Hormonal Dynamics at Midcycle: A Reevaluation.” J Clin Endocrinol Metab 57: 792-796, 1983. 

27. Reid, R.L., Quigley, M.E., and Yen, S.S.C. “Pituitary Apoplexy: A Review.” Archives of Neurology 42: 712-719, 1985. 

28. Martin, P.L., Greaney, M.O., Burnier, A.M., Brooks, P.M., Yen, S.S.C., and Quigley, M.E., “Estradiol, Estrone and Gonadotropin Levels After Use of Vaginal Estradiol.” Obstet Gyn 63: 441-444, 1984. 

29. Cetel, N.S., Quigley, M.E., and Yen, S.S.C. “Noloxone-Induced Prolactin Secretion In Women: Evidence Against A Direct Prolactin Stimulating Effect Of Endogenous Opioids.” J Clin Endocrinol Metab 60: 191-196, 1985. 

30. Mais, V., Muse, K.N., Cetel, M.S., Quigley, M.E., Reid, R.L., and Yen, S.S.C. “Hormonal Dynamics During the Luteal-Follicular Transition.” submitted 10/4/84, JCEM.

31. Yen, S.S.C, Quigley, M.E., Reid, R.L., Ropert, J.F., and Cetel, N.S. “Neuroendocrinology of Opioid Peptides and Their Role in the Control of Gonadotropin and Prolactin Secretion.” AJOG 152: 485-493. 1985. 

32. Quigley, M.E., Martin, P.L., and Burnier, A.M. “Estrogen Therapy Arrests Bone Loss in Elderly Women.” AJOG 156: 1516-1523, 1987. 

33. Suh, B.Y., Liu, J.H., Berga, S.L., Quigley, M.E., Laughlin, G.A., and Yen, S.S.C. “Hypercortisolism in Patients With Functional Hypothalamic Amenorrhea.” J Clin Endocrinol Metab 66: 733-739, 1988. 

34. Futterman, L.A., Jones, J.E., Miccio-Fonseca, L.C., and Quigley, M.E. “Assessing Premenstrual Syndrome Using the Premenstrual Experience Assessment.” Psychological Reports 63: 19-34, 1988. 

 

ABSTRACTS OF PRESENTATIONS:

1. Judd, S.J., Rakoff, J.S., Rigg, L.A., Quigley, M.E., and Yen, S.S.C. “Modulation of dopamine (DA) sensitivity for the release of LH and prolactin (PRL) by estrogen (E).” Presented at Society for Gynecological Investigation, Atlanta, Georgia. March 1978.

2. Quigley, M.E., Judd, S.J., and Yen, S.S.C. “Defective dopaminergic regulation of prolactin (PRL) and LH secretion in patients with hyperprolactinemic chronic anovulation associated with pituitary microadenomas (HCA).” Presented at Society for Gynecological Investigation, Atlanta,  Georgia. March 1978.

3. Quigley, M.E., Sheehan, K.L., Wilkes, M.M., and Yen, S.S.C. “Elucidation of mechanisms for the deleterious effects of maternal smoking on fetal well-being.” Presented at Society for Gynecological Investigation, Atlanta,  Georgia. March 1978.

4. Quigley, M.E., Gilliland, G.B., Judd, S.J., and Yen, S.S.C. “Defective dopaminergic regulation of prolactin (PRL) and LH secretion in patients with hyperprolactinemic chronic anovulation associated with pituitary microadenomas (HCA).” Presented at Endocrine Society, Miami, Florida. June 1978. 

5. Quigley, M.E., Sheehan, K.L., Casper, R.F., and Yen, S.S.C. “Evidence for increased endogenous opioid and dopamine (DA) activity in patients with hypothalamic hypogonadotropic amenorrhea (HHA).” Presented at Society for Gynecological Investigation, San Diego,  California. March 1979.

6. Quigley, M.E., Casper, R.F., Sheehan, K.L., and Yen, S.S.C. “Evidence for endogenous opioid excess in patients with hyperprolactinemic anovulation.” Presented at Society for Gynecological Investigation, San Diego,  California. March 1979.

7. Erickson, G.F., Hsueh, A.J.W., Quigley, M.E., Rebar, R.W., and Yen, S.S.C. “Aromatase deficiency in granulosa cells of polycistic ovary syndrome (PCO).” Presented at Society for Gynecological Investigation, San Diego,  California. March 1979.

8. Yen, S.S.C., Quigley, M.E., Sheehan, K.L., Casper, R.F. “Evidence for increased dopaminergic (DA) and endorphinergic activity in patients with hypothalamic hypogonadotropic amenorrhea (HHA) and hyperprolactinemic amenorrhea (HPA).” Presented at the Second International Symposium on Clinical Psycho-Neuro-Endocrinology in Reproduction, Venice, Italy. June 1979.  Presented by M.E. Quigley. 

9. Bruni, J.F., Stewart, R.D., Quigley, M.E., and Watkins, W.B. “Direct measurements of human B-endorphin in human biologic fluids, pancreas and adrenal, by a specific radioimmunoassay.” Presented at the Endocrine Society, Anaheim, California. June 1979. 

10. Cumming, D.C., Quigley, M.E., and Yen, S.S.C. “Increased dopaminergic inhibition of the ACTH-adrenal axis in women with hypothalamic amenorrhea (HA) and hyperprolactinemia with prolactinoma (HP).” Presented at the Society for Gynecologic Investigation, Denver, Colorado. March 1980. 

11. Quigley, M.E., and Yen, S.S.C. “Increased endogenous opioid-dopamine inhibition of LH secretion in the luteal phase of the menstrual cycle.” Presented at the Society for Gynecologic Investigation, Denver, Colorado. March 1980. 

12. Hoff, J.D., Quigley, M.E., and Yen, S.S.C. “Hormonal changes associated with the midcycle LH surge: A multiphasic rise in progesterone (P).” Presented at the Society for Gynecologic Investigation, Denver, Colorado. March 1980. 

13. Babaknia, A., Wilkes, M.M., Quigley, M.E., Kraus, P.F., Hoff, J.D., and Yen, S.S.C “Circadian rhythm in circulating concentration of deaminated metabolites of catecholamines (CA’s).” Presented at the Endocrine Society, Washington, D.C. June 1980. 

14. Quigley, M.E., and Yen, S.S.C. “Effects of opiate and dopamine receptor antagonists on serum LH during various phases of the menstrual cycle.” Presented at the Endocrine Society, Washington, D.C. June 1980. 

15. Hoff, J.D., and Quigley, M.E. “Hormonal changes associated with the midcycle LH surge: A multiphasic rise in progesterone.” Presented at the Endocrine Society, Washington, D.C. June 1980. 

16. Quigley, M.E., Robert, J.F. and Yen, S.S.C. “Feeding triggers prolactin (PRL) release in normal women but not patients with prolactinoma.” Presented at the Society of Gynecologic Investigation, St. Louis, Missouri. March 1981. 

17. Cumming, D.C., Quigley, M.E., Rebar, R.W., and Yen, S.S.C. “Reduced hypothalamic influences on LH secretion in polycystic ovarian disease (PCO).” Presented at the Pacific Coast Fertility Society, Rancho Mirage, California 1981. 

18. Ishizuka, B., Quigley, M.E., Ropert, J.F., and Yen, S.S.C. “Feeding triggers an acute prolactin (PRL) release in normal subjects but not in patients with prolactinoma.” Presented at the Pacific Coast Fertility Society, Rancho Mirage, California 1981.

19. Ishizuka, B. and Quigley, M.E. “The role of food ingestion in acute release of prolactin (PRL) and cortisol in humans.” Presented at the Endocrine Society, Cincinnati, Ohio. June 1981. 

20. Ishizuka, B., Yen, S.S.C., and Quigley, M.E. “Evidence for increased opioid inhibition of gonadotropin secretion during the puerperium in humans.” Presented at the Society for Gynecologic Investigation, Dalla, Texas. 1982. 

21. Quigley, M.E., Ropert, J.F., and Yen, S.S.C. “Concordance of pulsatile release of LH and prolactin (PRL) in normal women.” Presented at the Society for Gynecologic Investigation, Dalla, Texas. 1982. 

22. Quigley, M.E., Ishizuka, B., and Yen, S.S.C. “Evidence for increased opioid inhibition of gonadotropin secretion during the puerperium in humans.” Presented at the Endocrine Society, San Francisco, California. 1982. 

23. Cetel, N.S., Quigley, M.E., Robert, J.F., and Yen, S.S.C. “Synchronized pulsatile release of prolactin and luteinizing hormone in normal cycling and hypogonadal women.” Presented at the Endocrine Society, San Francisco, California. 1982. 

24. Silva de Sa, M.F., Quigley, M.E., and Rebar, R.W. “Different molecular forms of human prolactin secreted by pituitary tumors.” Presented at Brazilian Meeting of Gynecology and Obstetrics, Rio de Janeiro. November 1982. 

25. Rasmussen, D.D., Ishizuka, B., and Quigley, M.E. “Pituitary hormone release in response to food ingestion; neuroendocrine regulation by metabolic signals from gut to brain.” Presented at the Endocrine Society. 1983. 

26. Cetel, N.S., Quigley, M.E., and Yen, S.S.C. “Paradoxical release of prolactin (PRL) in response to naloxone infusion in man.” Presented at the Society for Gynecologic Investigation, Phoenix, Arizona. 1983. 

27. Cetel, N.S., Muse, K., Mais, V., Quigley, M.E., and Yen, S.S.C. “Hormonal dynamics during luteal follicular transition.” Presented at the Society of Gynecologic Investigation, Phoenix, Arizona. 1983. 

28. Liu, L.H., Quigley, M.E., and Yen, S.S.C. “Further characterization of the pulsatile of luteinizing hormone during the follicular phase of cycle.” Presented at the Society of Gynecologic Investigation. 1984. 

29. Quigley, M.E., Martin, P.L., and Burnier, A.M. “Estrogen Therapy Arrests Bone Loss in Elderly Women.” Presented at the Pacific Coast Obstetrics and Gynecology Society, Tucson, Arizona, 1984.

30. Settle, A.B., and Quigley, M.E. “ Biological rhythms of luteinizing hormone, prolactin and cortisol in patients with hypothalamic amenorrhea and normal women.”  Presented at the Society of Gynecologic Investigation, Phoenix, Arizona. 1985. 

 

After leaving academic medicine at UCSD in September 1982, Dr. Quigley went into private practice. His primary commitment was to patient care and education. Over the years, Dr. Quigley has spoken at the hospital grand rounds and OB/GYN departmental rounds at most of the major hospitals in Southern California. 

Dr. Quigley has spoken to over 5000 doctors in the United States at CMEA semi-annual seminars for obstetricians and gynecologists, internist and family practice physicians. Dr. Quigley made a major contribution to Ruth S. Jacobowitz’ book, 150 Most Asked Questions About Midlife Sex, Love and Intimacy, published in 1995, where he related his fifteen years of experience in treating women with testosterone. As a result of this book, Dr. Quigley appeared in two segments of CBS' program, 48 Hours- one dealing with testosterone replacement in women, and the other dealing with andropause and testosterone replacement in men for midlife wellness. These were viewed in February 1995. 

Dr. Quigley has appeared many times on local TV and radio talk shows in Southern California, discussing menopause, PMS, postpartum depression, testosterone for women, risks versus benefits of ERT/HRT, breast cancer and HRT, osteoporosis, heart disease, Alzheimer’s disease, and cognitive changes with perimenopause and andropause. 

Dr. Quigley was featured in USA Today, in an article about his treatment of perimenopausal problems. He also appeared in the June 1997 issue of Physician’s Newsweek, where he favored the use of Estrogen Replacement Therapy (ERT) in postmenopausal women who had a bold FSH level. 

Dr. Quigley has spoken at numerous women’s health seminars throughout Southern California. He coordinated and co-chaired the first Women’s Health Day, sponsored at Sharp Memorial Hospital in 1982. He was the originator of an office-based series of annual seminars for patients of private practitioners. The first seminar was given in the spring of 1983 and addressed the role of ERT/HRT in improveing the quality of life for postmenopausal women. Each seminar was attended by between 300-1500 women in San Diego. These annual seminars were co-sponsored by Sharp Memorial Hospital, Mercy Hospital and Scripps Memorial Hospital. On October 19, 2002 at the 20th Annual Midlife Wellness Seminar, Dr. Quigley discussed the many concerns he had in the much-publicized Women's Health Initiative (WHI) study that created havoc causing many menopausal women. After voicing his concerns about the study design, data, and interpretation of the data, he reviewed what he learned from the study, which modified his approach to HRT; however, he reiterated that each woman needs to decide her own HRT path based on her intuition. 

Dr. Quigley completed writing a book,  MeNoPause: Awaken and Empower yourSelf with Bio-identical Hormone Replacement Therapy,  on midlife physical, mental and spiritual wellness for women.